期刊
NANO LETTERS
卷 12, 期 12, 页码 6049-6054出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl300051g
关键词
DNA; DNAzyme; logic gates; biocomputing; field-programmable; pH
类别
资金
- EU MOLOC project
- Office of Naval Research, U.S.A
- Converging Technologies Fellowship (Israel Science Foundation)
Nature performs complex information processing circuits, such the programmed transformations of versatile stem cells into targeted functional cells. Man-made molecular circuits are, however, unable to mimic such sophisticated biomachineries. To reach these goals, it is essential to construct programmable modular components that can be triggered by environmental stimuli to perform different logic circuits. We report on the unprecedented design of artificial pH-programmable DNA logic arrays, constructed by modular libraries of Mg2+- and UO22+-dependent DNAzyme subunits and their substrates. By the appropriate modular design of the DNA computation units, pH-programmable logic arrays of various complexities are realized, and the arrays can be erased, reused, and/or reprogrammed. Such systems may be implemented in the near future for nanomedical applications by pH-controlled regulation of cellular functions or may be used to control biotransformations stimulated by bacteria.
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