期刊
NANO LETTERS
卷 12, 期 11, 页码 5587-5592出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl302643g
关键词
Multimodular proteins; fibrillogenesis; surface assembly; matrix elasticity; plastic deformation
类别
资金
- Defense Advanced Research Projects Agency CINAPSE [W911NF-10-1-0113]
- National Science Foundation [PHY-0646094, DMR-0213805]
- Draper Lab Fellowship
- School of Engineering and Applied Sciences, Harvard University
- Kavli Institute at Harvard University
- Harvard University Nanoscale Science and Engineering Center
- Harvard University Materials Research Science and Engineering Center
Fibronectin (FN) textiles are built as nanometer-thick fabrics. When uniaxially loaded, these fabrics exhibit a distinct threshold between elastic and plastic deformation with increasing stretch. Fabric mechanics are modeled using an eight chain network and two state model, revealing that elastic properties of FN depend on conformational extension of the protein and that plastic deformation depends on domain unfolding. Our results suggest how the molecular architecture of a molecule can be exploited for designer mechanical properties of a bulk material.
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