期刊
NANO LETTERS
卷 11, 期 2, 页码 541-547出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl1034489
关键词
Background-free detection; gold nanoparticles; polarization microscopy; crossed polarizers; heterodyne detection; interferometry
类别
资金
- Biotechnology and Biological Sciences Research Council through a Technology Development Research Initiative [BB/F004494/1]
- Royal Society [NF082381]
- ICREA-Institucio Catalana de Recerca i Estudis Avancats (Barcelona)
- Royal Society [NF082381] Funding Source: Royal Society
- Biotechnology and Biological Sciences Research Council [BB/F004494/1] Funding Source: researchfish
- BBSRC [BB/F004494/1] Funding Source: UKRI
Metal nanoparticles play a key role in sensing and imaging. Here we demonstrate the detection of metal particles down to 5 nm in size with a signal-to-noise ratio of similar to 7 using interferometric cross-polarization microscopy at ultralow excitation powers (similar to 1 mu W) compatible with single molecule detection. The method is background-free and induces no heating as it operates far from plasmonic resonance. The combination of unlimited observation time and protein-sized metal nanoparticles has great potential for biophysical applications.
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