期刊
NANO LETTERS
卷 11, 期 5, 页码 2152-2156出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl200801n
关键词
Drug delivery; encapsulation; nanoparticles; cell membranes; nanostructures
类别
资金
- Max Planck Society
- Deutsche Forschungsgemeinschaft [MO283/38-1]
- DEST through ISI [CG110036]
Biocompatibility is of paramount importance for drug delivery, tumor labeling, and in vivo application of nanoscale bioprobes. Until now, biocompatible surface processing has typically relied on PEGylation and other surface coatings, which, however, cannot minimize clearance by macrophages or the renal system but may also increase the risk of chemical side effects. Cell membranes provide a generic and far more natural approach to the challenges of encapsulation and delivery in vivo. Here we harness for the first time living cells as factories to manufacture cell membrane capsules for encapsulation and delivery of drugs, nanoparticles, and other biolabels. Furthermore, we demonstrate that the built-in protein channels of the new capsules can be utilized for controlled release of encapsulated reagents.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据