期刊
NANO LETTERS
卷 11, 期 9, 页码 3720-3726出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl201978c
关键词
Nanoparticle; coating; phospholipid-PEG; solvent exchange
类别
资金
- National Heart Lung and Blood Institute of the NIH [HHSN268201000043C]
- NIH Nanomedicine Development Center [PN2 EY018244]
- Provincia Autonoma di Trento, Italy
We coated nanopartides including iron oxide nanoparticles and quantum dots with phospholipid-PEG using the newly developed dual solvent exchange method and demonstrated that, compared with the conventional film hydration method, the coating efficiency and quality of coated nanoparticles can be significantly improved. Abetter control of surface coating density and the amount of reactive groups on nanoparticle surface is achieved, allowing conjugation of different moieties with desirable surface concentrations, thus facilitating biomedical applications of nanoparticles.
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