期刊
NANO LETTERS
卷 11, 期 10, 页码 4411-4414出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl2025882
关键词
Liposomes; myocardial infarction; nanoparticles; targeting
类别
资金
- NIH [EB000244, EB006365, HL 086967, GM073626]
- American Heart Association
- Misrock Foundation
We report a nanoparticulate system capable of targeting the heart after myocardial infarction (MI). Targeting is based on overexpression of angiotensin II type 1 (AT1) receptor in the infarcted heart. Liposomes 142 nm in diameter were conjugated with a ligand specific to AT1. The nanoparticles were able to specifically target cardiac cells in vitro, and in the infarcted heart after intravenous injection in vivo. This system may be useful for delivering therapeutic agents specifically to the infarcted heart.
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