期刊
NANO LETTERS
卷 11, 期 3, 页码 1076-1081出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl103951e
关键词
Nanowires; adhesion; drug delivery; hierarchical nanostructures
类别
资金
- NSF
- NIH [EB01166401]
- Rogers Foundation
- University of California
- Nanosys, Inc
To circumvent the barriers encountered by macromolecules at the gastrointestinal mucosa, sufficient therapeutic macromolecules must be delivered in close proximity to cells.(1) Previously, we have shown that silicon nanowires penetrate the mucous layer and adhere directly to cells under high shear.(2) In this work, we characterize potential reservoirs and load macromolecules into interstitial space between nanowires. We show significant increases in loading capacity due to nanowires while retaining adhesion of loaded particles under high shear.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据