期刊
NANO LETTERS
卷 11, 期 11, 页码 4932-4938出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl2028766
关键词
Europium hydroxide [Eu-III(OH)(3)] nanorods; reactive oxygen species; hydrogen peroxide (H2O2); single-walled carbon nanotubes; in vivo angiogenesis; zebrafish model
类别
资金
- National Institutes of Health (NIH) [HL70567, CA150190, HL090712]
- DST, Govt. of India, New Delhi [SR/S2/RJN-04/2010, GAP 0305\DST\CP]
- Children's Research Institute
The exact mechanism of angiogenesis by europium hydroxide nanorods was unclear. In this study we have showed that formation of reactive oxygen species (H2O2 and O-2 center dot-) is involved in redox signaling pathways during angiogenesis, important for cardiovascular and ischemic diseases. Here we used single-walled carbon nanotube sensor array to measure the single-molecule efflux of H2O2 and a HPLC method for the determination of O-2 center dot- from endothelial cells in response to proangiogenic factors. Additionally, reactive oxygen species-mediated angiogenesis using inorganic nanorods was observed in transgenic (flila:EGFP) zebrafish embryos.
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