期刊
NANO LETTERS
卷 11, 期 7, 页码 2579-2583出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl1026056
关键词
Biosensors; nanobiotechnology; antibody cross-reactivity; giant magnetoresistance; magnetic nanoparticles
类别
资金
- National Cancer Institute [1U54CA119367, 1U54CA143907]
- National Science Foundation (NSF) [ECCS-0801385-000]
- Defense Threat Reduction Agency [HDTRA1-07-1-0030-P00005]
- National Semiconductor Corporation
- Stanford Medical School
- Directorate For Engineering
- Div Of Electrical, Commun & Cyber Sys [0801385] Funding Source: National Science Foundation
We report an autoassembly protein array capable of rapidly screening for aberrant antibody-antigen binding events. Our technique combines magnetic nanoparticle technology with proximity-based, magnetically responsive nanosensors for rapid (under 15 min) and high-density screening of antibody cross-reactivity at sensitivities down to 50 fM in a homogeneous assay. This method will enable the identification of the precise cause of aberrant or cross-reactive binding events in an easy-to-use, rapid, and high-throughput manner.
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