期刊
NANO LETTERS
卷 11, 期 2, 页码 694-700出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl103812a
关键词
Nanoparticles; ischemia; VEGF; drug delivery; imaging; therapeutic angiogenesis; targeting
类别
资金
- Wyss Institute for Biologically Inspired Engineering at Harvard University,
- National Institutes of Health [R01 HL069957]
- EMBO Long-Term Fellowship [ALTF 42-2008]
Targeting of nanoparticles to, ischemic tissues was studied in a murine ischemic hindlimb model. Intravenously injected fluorescent nanoparticles allowed ischemia-targeted imaging of ischemic muscles due to increased permeability of blood vessels in hypoxic tissues. Targeting efficiency correlated with blood perfusion after induction of ischemia and was enhanced in early stages of ischemia (<7 days). Therapeutic delivery of vascular endothelial growth factor (VEGF) was achieved by VEGF-conjugated nanoparticles and resulted in a 1.7-fold increase in blood perfusion, as compared to control mice. This work supports the application of nanoparticles as imaging and therapeutic modalities for ischemia treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据