期刊
NANO LETTERS
卷 11, 期 5, 页码 1941-1945出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl200147x
关键词
DNA sequencing; graphene; nanogap; ab initio; electronic transport; molecular electronics
类别
资金
- Royal Thai Government
- Carl Tryggers Foundation
- Uppsala University UniMolecular Electronics Center (U3MEC)
- Wenner-Gren Foundations
- Swedish Foundation for International Cooperation in Research and Higher Education (STINT)
- Swedish Research Council (VR) [621-2009-3628]
The fabrication of nanopores in atomically thin graphene has recently been achieved, and translocation of DNA has been demonstrated. Taken together with an earlier proposal to use graphene nanogaps for the purpose of DNA sequencing, this approach can resolve the technical problem of achieving single-base resolution in electronic nucleobase detection. We have theoretically evaluated the performance of a graphene nanogap setup for the purpose of whole-genome sequencing, by employing density functional theory and the nonequilibrium Green's function method to investigate the transverse conductance properties of nucleotides inside the gap. In particular, we determined the electrical tunneling current variation at finite bias due to changes in the nucleotides orientation and lateral position. Although the resulting tunneling current is found to fluctuate over several orders of magnitude, a distinction between the four DNA bases appears possible, thus ranking the approach promising for rapid whole-genome sequencing applications.
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