期刊
NANO LETTERS
卷 11, 期 7, 页码 2938-2943出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl2014394
关键词
Gold nanorods; sentinel lymph node; phothothermal; optical coherence tomography
类别
资金
- National Heart, Lung, and Blood Institute [R01 HL093140]
- National Institute of Biomedical Imaging and Bioengineering [R01 EB009682]
- American Heart Association [0855733G]
In this paper, we demonstrate an application of a noninvasive imaging modality, photothermal optical coherence tomography (PT-OCT), for imaging gold nanorods (GNRs) uptake in sentinel lymph node (SLN) of mice in situ. This application enables us to obtain higher quality images of SLN structures due to the photothermal contrast properties of the GNRs. It is also demonstrated that GNRs accumulate differently within several SLN structures, and this uptake is time dependent. Finally, we determine the average concentration of GNRs within the whole SLN which is used to demonstrate uptake kinetics of the nanoparticles.
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