期刊
NANO LETTERS
卷 11, 期 1, 页码 176-182出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl103334q
关键词
Single-molecule electronics; nanobioelectronics; cytochrome b(562); protein engineering; scanning tunneling microscopy; redox-gated tunneling resonance
类别
资金
- Cardiff University
- EPSRC [EP/D076072/1]
- BBSRC [BB/E001084]
- Danish Research Council for Technology and Production Sciences [274-07-0272]
- Engineering and Physical Sciences Research Council [EP/D076072/1] Funding Source: researchfish
Cytochrome b(562) was engineered to introduce a cysteine residue at a surface-exposed position to facilitate direct self-assembly on a Au(111) surface. The confined protein exhibited reversible and fast electron exchange with a gold substrate over a distance of 20 angstrom between the heme redox center and the gold surface, a clear indication that a long-range electron-transfer pathway is established. Electrochemical scanning tunneling microscopy was used to map electron transport features of the protein at the single molecule level. Tunneling resonance was directly imaged and apparent molecular conductance was measured, which both show strong redox-gated effects. This study has addressed the first case of heme proteins and offered new perspectives in single-molecule bioelectronics.
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