期刊
NANO LETTERS
卷 11, 期 1, 页码 73-78出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl102821f
关键词
Glyco-polymer; continuous flow reactor; [2+2] photocycloaddition; protein carbohydrate interaction; bacteria detection
类别
资金
- Max-Planck Society
- Merck Sharp Dohme
Biocompatible glyco-dendronized poly-L-lysine (PLL) polymers carry either three or nine mannose- or galactose-bearing dendrons that selectively bind, and thus can be used to detect, bacteria. Central to the synthesis of glyco-dendronized polymers was the development of a continuous flow [2 + 2] photocycloaddition reaction to connect the dendrons and PLL. Glycodendronized polymers cluster bacteria by binding to cell-surface carbohydrate receptors and thereby result in an easy read-out using microscopic analyses.
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