期刊
NANO LETTERS
卷 11, 期 7, 页码 2678-2683出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl200858y
关键词
Gold nanoparticles; X-ray scattering; spatial harmonic imaging; layer-by-layer assembly; hepatocellular carcinoma; early diagnosis
类别
资金
- U.S. Department of Energy [DE-FG02-08ER15937]
- US Department of Education through GAANN [P200A090076]
- National Institutes of Health [CA123544]
- U.S. Department of Energy (DOE) [DE-FG02-08ER15937] Funding Source: U.S. Department of Energy (DOE)
We present the development of a new imaging technique for the early diagnosis of hepatocellular carcinoma that utilizes surface-modified gold nanopartides in combination with X-ray imaging. Tissues labeled with these electron-dense particles show enhanced X-ray scattering over normal tissues, distinguishing cells containing gold nanoparticles from cells without gold in X-ray scatter images. Our results suggest that this novel approach could enable the in vivo detection of tumors as small as a few millimeters in size.
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