期刊
NANO LETTERS
卷 10, 期 8, 页码 2915-2921出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl101046t
关键词
DNA sequencing; atomic layer deposition; single molecule; nanopores
类别
资金
- NIH [R21HG004767]
- JSTO DTRA
- Army Research Office [W911NF-06-1-0462]
- Penn Genome Frontiers Institute
- Nanotechnology Institute of the Commonwealth of Pennsylvania
- Pennsylvania Department of Health
- Nano/Bio Interface Center through the National Science Foundation NSEC [DMR08-32802]
- NSF [DGE-0221664]
We report on DNA translocations through nanopores created in graphene membranes. Devices consist of 1-5 nm thick graphene membranes with electron-beam sculpted nanopores from 5 to 10 nm in diameter. Due to the thin nature of the graphene membranes, we observe larger blocked currents than for traditional solid-state nanopores. However, ionic current noise levels are several orders of magnitude larger than those for silicon nitride nanopores. These fluctuations are reduced with the atomic-layer deposition of 15 nm of titanium dioxide over the device. Unlike traditional solid-state nanopore materials that are insulating, graphene is an excellent electrical conductor. Use of graphene as a membrane material opens the door to a new class of nanopore devices in which electronic sensing and control are performed directly at the pore.
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