4.8 Article

Rapid Sequencing of Individual DNA Molecules in Graphene Nanogaps

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NANO LETTERS
卷 10, 期 2, 页码 420-425

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AMER CHEMICAL SOC
DOI: 10.1021/nl9029237

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DNA; sequencing; graphene

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I propose a technique for reading the base sequence of a single DNA molecule using a graphene nanogap to read the DNA's transverse conductance. Because graphene is a single atom thick, single-base resolution of the conductance is readily obtained. The nonlinear current-voltage characteristic is used to determine the base type independent of nanogap-width variations that cause the current to change by 5 orders of magnitude. The expected sequencing error rate is 0% up to a nanogap width of 1.6 nm.

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