期刊
NANO LETTERS
卷 10, 期 6, 页码 2168-2172出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl100890d
关键词
Photoacoustic molecular imaging; carbon nanotube
类别
资金
- National Institute of Health (NIH) [NCI CCNE U54 CA119367, NCI ICMIC P50 CA 1 14747]
- Canary Foundation
- Bio-X Graduate Student Fellowship
- DoD Breast Cancer Research
Photoacoustic imaging is an emerging modality that overcomes to a great extent the resolution and depth limitations of optical imaging while maintaining relatively high-contrast. However, since many diseases will not manifest an endogenous photoacoustic contrast, it is essential to develop exogenous photoacoustic contrast agents that can target diseased tissue(s). Here we present a novel photoacoustic contrast agent, Indocyanine Green dye-enhanced single walled carbon nanotube (SWNT-ICG). We conjugated this contrast agent with cyclic Arg-Gly-Asp (RGD) peptides to molecularly target the alpha(nu)beta(3) integrins, which are associated with tumor angiogenesis. Intravenous administration of this tumor-targeted contrast agent to tumor-bearing mice showed significantly higher photoacoustic signal in the tumor than in mice injected with the untargeted contrast agent. The new contrast agent gave a markedly 300 times higher photoacoustic contrast in living tissues than previously reported SWNTs, leading to subnanomolar sensitivities. Finally, we show that the new contrast agent can detect similar to 20 times fewer cancer cells than previously reported SWNTs.
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