期刊
NANO LETTERS
卷 10, 期 1, 页码 52-58出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl902659g
关键词
Angiogenesis; magnetic resonance imaging; molecular imaging; synergistic targeting; anti-angiogenic therapy
类别
资金
- BSIK project entitled Molecular Imaging of Ischemic Heart Disease [BSIK03033]
- European Network of Diagnostic Molecular Imaging (DIMI) [LSHB-CT-2005-512146]
- Integrated European Union Project Targeted Delivery of Nanomedicine [FP6_2004_NMP_NI_4/IP 026668_2]
Effective and specific targeting or nanoparticles is of paramount importance in the fields of targeted therapeutics and diagnostics. In the Current study, we investigated the targeting efficacy of nanoparticles that were functionalized with two angiogenesis-specific targeting ligands, an alpha(v)beta(3) integrin-specific and a galectin-1-specific peptide. We show in vitro, using optical techniques and MRI, that the dual-targeting approach produces synergistic targeting effects, causing a dramatically elevated uptake of nanoparticles as compared to single ligand targeting.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据