期刊
NANO LETTERS
卷 10, 期 5, 页码 1664-1670出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl9042483
关键词
Carbon nanotube; biocompatible; purification; toxicity; safety
类别
资金
- National Institute of Health [ES015024, ES013995, HL071643, HL067835]
- Northwestern University Clinical and Translational Sciences Institute (NUCATS) Center for Translational Innovation (CTI) [UL1 RR025741]
- National Center for Research Resources (NCCR)
- National Institutes of Health (NIH)
- NIH Roadmap for Medical Research
- American Lung Association
- U.S.-Israel Binational Science Foundation
- Natural Sciences and Engineering Research Council of Canada
- Institute for Bionanotechnology in Medicine [NCI CCSG P30 CA060553]
Excitement surrounding the attractive physical and chemical characteristics of single walled carbon nanotubes (SWCNTs) has been tempered by concerns regarding their potential health risks. Here we consider the lung toxicity of nanoscale dispersed SWCNTs (mean diameter similar to 1 nm). Because dispersion of the SWCNTs increases their aspect ratio relative to as-produced aggregates, we directly test the prevailing hypothesis that lung toxicity associated with SWCNTs compared with other carbon structures is attributable to the large aspect ratio of the individual particles. Thirty days after their intratracheal administration to mice, the granuloma-like structures with mild fibrosis in the large airways observed in mice treated with aggregated SWCNTs were absent in mice treated with nanoscale dispersed SWCNTs. Examination of lung sections from mice treated with nanoscale dispersed SWCNTs revealed uptake of the SWCNTs by macrophages and gradual clearance over time. We conclude that the toxicity of SWCNTs in vivo is attributable to aggregation of the nanomaterial rather than the large aspect ratio of the individual nanotubes. Biocompatible nanoscale dispersion provides a scalable method to generate purified preparations of SWCNTs with minimal toxicity, thus allowing them to be used safely in commercial and biomedical applications.
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