期刊
NANO LETTERS
卷 10, 期 1, 页码 250-254出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl903411s
关键词
Nanoparticles; cell targeting; caging group; light; drug delivery
类别
资金
- NIH [GM073626]
- American Heart Association
- Helen Hay Whitney Foundation
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM073626] Funding Source: NIH RePORTER
We report a novel and simple proof-of-concept of a nanoparticulate system that targets any tissue selectively upon illumination. Nanoparticles were covalently functionalized with the amino acid sequence YIGSR, which adheres to the beta 1 integrins present on most cell surfaces, This peptide was masked with a caging group, rendering it biologically inert. Illumination with UV light released the caging group from the YIGSR, allowing binding to cells.
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