期刊
NANO LETTERS
卷 10, 期 6, 页码 2184-2191出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl100998p
关键词
Extracellular matrix protein; fibronectin; laminin; nanofiber; soft lithography; cardiac; tissue engineering
类别
资金
- DARPA
- Air Force Office
- Harvard Materials Research Science and Engineering Center (MRSEC)
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [820484] Funding Source: National Science Foundation
Cells and tissues are self-organized within an extracellular matrix (ECM) composed of multifunctional, nano- to micrometer scale protein fibrils. We have developed a cell-free, surface-initiated assembly technique to rebuild this ECM structure in vitro. The matrix proteins fibronectin, laminin, fibrinogen, collagen type I, and collagen type IV are micropatterned onto thermosensitive surfaces as 1 to 10 nm thick, micrometer to centimeter wide networks, and released as flexible, free-standing nanofabrics. Independent control of microstructure and protein composition enables us to engineer the mechanical and chemical anisotropy. Hbronectin nanofabrics are highly extensible (>4-fold) and serve as scaffolds for engineering synchronously contracting, cardiac muscle: demonstrating biofunctionality comparable to cell-generated ECM.
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