期刊
NANO LETTERS
卷 10, 期 11, 页码 4697-4701出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl102986v
关键词
DNA; peptide nucleic acid; optical tweezers; microfluidic cross-slot; single-molecule; sequence-specific
类别
资金
- NIH [R21HG4342, GM32543, GMOZ1552]
- NSF
The ability to strongly and sequence-specifically attach modifications such as fluorophores and haptens to individual double-stranded (ds) DNA molecules is critical to a variety of single-molecule experiments. We propose using modified peptide nucleic acids (PNAs) for this purpose and implement. them in two model single-molecule experiments where individual DNA molecules are manipulated via microfluidic flow and optical tweezers, respectively. We demonstrate that PNAs are versatile and robust sequence-specific tethers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据