期刊
NANO LETTERS
卷 10, 期 10, 页码 3933-3939出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl1016909
关键词
Nanoparucles; Si RNA; chitosan; nerve regeneration; nanobiofunctionalized implants; drug delivery
类别
资金
- EU
- Landesstiftung Baden-Wurttemberg, P-LS-Biornat/26
- Portuguese Foundation for Science and Technology [POCl/ SAU-BMA/58 I 70/2004]
Microstructured 2 0 Aim thick polymer filaments used as nerve implants were loaded with chitosan/siRNA nanoparucles to promote nerve regeneration and ensure local delivery of nanotherapeutics The stable nanoparticles were rapidly internalized by cells and did not affect cell viability Target mRNA was successfully reduced by 65-75% and neurite outgrowth was enhanced even in an inhibitory environment This work, thus. supports the application of nanobiofunctionalized implants as a novel approach for spinal cord and nerve repair
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据