期刊
NANO LETTERS
卷 9, 期 12, 页码 4066-4072出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl902256b
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资金
- National Basic Research Program of China [2009CB930100]
- National Natural Science Foundation of China [20911130229]
- CAS Key Laboratory of Nano Bioeffect and Biosafety
We report here a single molecular approach using chaperone-like molecular modulators for modulating the aggregation behavior of a vital analogue of beta-amyloid peptide (A beta) by using scanning tunneling microscopy. The molecular structures of the beta-sheets for A beta 33-42 peptide are revealed, which are keen to the aggregation of A beta 42 relating to Alzheimer's disease. It was identified that the introduction of chaperone-like modulators could regulate the assembling behavior of the peptide at molecular level. Furthermore, the modulators could also significantly accelerate the aggregation of the peptide in aqueous solution as revealed by light scattering studies. These observations of the molecular modulator effect in peptide assemblies could provide a novel approach toward modulating A beta peptide aggregations.
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