期刊
NANO LETTERS
卷 9, 期 3, 页码 945-951出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl802813f
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资金
- U.S. Department of Energy [DE-FG02-00ER45810]
- National Science Foundation [DMR-0605427]
- MRSEC at Northwestern University [NSF DMR-0520513]
- NSEC at Northwestern University [NSEC EEC-0647560]
- National Institutes of Health [NIH/NIBIB 5R01EB003806]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB003806] Funding Source: NIH RePORTER
Many alkylated peptide amphiphiles have been reported to self-assemble into cylindrical nanofibers with diameters on the order of a few nanometers and micrometer scale lengths; these nanostructures can be highly bioactive and are of great Interest in many biomedical applications. We have discovered the sequences for these molecules that can eliminate all curvature from the nanostructures they form In water and generate completely flat nanobelts with giant dimensions relative to previously reported systems. The nanobelts have fairly monodisperse widths on the order of 150 nm and lengths of up to 0.1 mm. The sequences have an alternating sequence with hydrophobic and hydrophilic side chains and variations in monomer concentration generate a broom morphology with twisted ribbons that reveals the mechanism through which giant nanobelts form. Interestingly, a variation in pH generates reversibly periodic 2 nm grooves on the surfaces of the nanobelts. With proper functionalization, these nanostructures offer a novel architecture to present epitopes to cells for therapeutic applications.
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