期刊
NANO LETTERS
卷 9, 期 5, 页码 2193-2198出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl901047u
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资金
- NSF [DMI 0328162, CBET 0731096]
- Grainger Foundation
- NIH [GM072744]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0933223] Funding Source: National Science Foundation
Studying molecular dynamics inside living cells is a major but highly rewarding challenge in cell biology. We present a nanoscale mechanochemical method to deliver fluorescent quantum dots (QDs) into living cells, using a membrane-penetrating nanoneedle. We demonstrate the selective delivery of monodispersed QDs into the cytoplasm and the nucleus of living cells and the tracking of the delivered QDs inside the cells. The ability to deliver and track QDs may invite unconventional strategies for studying biological processes and biophysical properties in living cells with spatial and temporal precision, potentially with molecular resolution.
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