期刊
NANO LETTERS
卷 9, 期 9, 页码 3337-3342出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl901610f
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- U.S. Department of Energy, Office of Basic Energy Sciences [DE-AC02-06CH11357]
- National Cancer Institute [R01-CA1 22930, R21-CA135728 MSL]
- National Institute of Neurological Disorders and Stroke [K08-NS046430]
- Alliance for Cancer Gene Therapy Young Investigator Award
- American Cancer Society [RSG-07-276-01-MGO]
- Brain Research Foundation [FAS 6-33186]
- NATIONAL CANCER INSTITUTE [R21CA135728, R01CA122930] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [K08NS046430] Funding Source: NIH RePORTER
We report pronounced and specific antiglioblastoma cell phototoxicity of 5 nm TiO2 particles covalently tethered to an antibody via a dihydroxybenzene bivalent linker. The linker application enables absorption of a visible part of the solar spectrum by the nanobio hybrid. The phototoxicity is mediated by reactive oxygen species (ROS) that initiate programmed death of the cancer cell. Synchrotron X-ray fluorescence microscopy (XFM) was applied for direct visualization of the nanobioconjugate distribution through a single brain cancer cell at the submicrometer scale.
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