期刊
NANO LETTERS
卷 9, 期 2, 页码 751-757出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl8033174
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- University of New Mexico [IRG-92-024]
We demonstrate that dispersion of single walled carbon nanotubes (SWNTs) by ultrasonication with phospholipid-polyethylene glycol (PL-PEG) fragments it, thus interfering with its ability to block nonspecific uptake by cells. However, unfragmented PL-PEG promoted specific cellular uptake of targeted SWNTs to two distinct classes of receptors expressed by cancer cells. Since fragmentation is a likely consequence of ultrasonication, a technique commonly used to disperse SWNTs, this maybe a concern for certain applications such as drug delivery.
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