期刊
NANO LETTERS
卷 8, 期 9, 页码 2800-2805出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl801362a
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资金
- NIH [T32 CA09695-15]
- [NCI CCNE U54 CA119367]
- [NIBIB BRP 5-RO1-EBB000312]
- [ICMIC P50 CA114747]
- NATIONAL CANCER INSTITUTE [P50CA114747, U54CA119367, R01CA119053, R21CA102123, T32CA009695] Funding Source: NIH RePORTER
An optimized noninvasive Raman microscope was used to evaluate tumor targeting and localization of single walled carbon nanotubes (SWNTs) in mice. Raman images were acquired in two groups of tumor-bearing mice. The control group received plain-SWNTs, whereas the experimental group received tumor targeting RGD-SWNTs intravenously. Raman imaging commenced over the next 72 h and revealed increased accumulation of RGD-SWNTs in tumor (p < 0.05) as opposed to plain-SWNTs. These results support the development of a new preclinical Raman imager.
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