期刊
NANO LETTERS
卷 8, 期 10, 页码 3409-3412出版社
AMER CHEMICAL SOC
DOI: 10.1021/nl802142h
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资金
- NIH [HL73937]
- NSF [0555329]
- DOE [DE-FG02-07ER46428]
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [0555329] Funding Source: National Science Foundation
Cardiac fibroblasts, the noncontractile cells of the heart, contribute to myocardial maintenance through the deposition, degradation, and organization of collagen. Adding polyelectrolyte-coated gold nanorods to three-dimensional constructs composed of collagen and cardiac fibroblasts reduced contraction and altered the expression of mRNAs encoding beta-actin, alpha-smooth muscle actin, and collagen type I. These data show that nanomaterials can modulate cell-mediated matrix remodeling and suggest that the targeted delivery of nanomaterials can be applied for antifibrotic therapies.
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