期刊
MYCOSES
卷 57, 期 7, 页码 389-393出版社
WILEY-BLACKWELL
DOI: 10.1111/myc.12168
关键词
Luliconazole; antifungal; onychomycosis; topical; dermatophyte; Trichophyton rubrum
资金
- Topica Pharmaceuticals Inc.
Luliconazole is a novel, broad-spectrum, imidazole antifungal under development in the USA as a treatment for dermatophytic skin and nail infections. In vitro, luliconazole is one of the most potent antifungal agents against filamentous fungi including dermatophytes. Luliconazole has been formulated in a 10% solution with unique molecular properties, which allow it to penetrate the nail plate and rapidly achieve fungicidal levels in the nail unit. These properties make luliconazole a potent compound in the treatment of onychomycosis. This article reviews the development of luliconazole solution, 10% its molecular properties, preclinical and clinical data and its future perspectives for the treatment of fungal infections.
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