期刊
SENSORS
卷 15, 期 5, 页码 10481-10510出版社
MDPI AG
DOI: 10.3390/s150510481
关键词
surface plasmon resonance; SPR; biosensor; SPR imaging; applications
资金
- R&D Convergence Program of the Korea Research Council of Fundamental Science and Technology (KRCF)
- KRIBB Initiative Research Program (KRIBB, Korea)
- National Research Council of Science & Technology (NST), Republic of Korea [KGM5141511] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [22A20130012280] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Surface plasmon resonance (SPR) is a label-free detection method which has emerged during the last two decades as a suitable and reliable platform in clinical analysis for biomolecular interactions. The technique makes it possible to measure interactions in real-time with high sensitivity and without the need of labels. This review article discusses a wide range of applications in optical-based sensors using either surface plasmon resonance (SPR) or surface plasmon resonance imaging (SPRI). Here we summarize the principles, provide examples, and illustrate the utility of SPR and SPRI through example applications from the biomedical, proteomics, genomics and bioengineering fields. In addition, SPR signal amplification strategies and surface functionalization are covered in the review.
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