期刊
MYCOPATHOLOGIA
卷 170, 期 4, 页码 213-221出版社
SPRINGER
DOI: 10.1007/s11046-010-9316-3
关键词
Grafting; Polyethylenimine; Dimethylaminoethylmethacrylate; Candida albicans; Biofilm; Modified Robbins Device
类别
资金
- Belgian Federation against Cancer
- Fund for Scientific Research FWO-Flanders
Candida albicans biofilms are a major cause of voice prosthesis deterioration in laryngectomized patients. The aim of this study was to produce a surface capable of inhibiting C. albicans biofilm formation. Dimethylaminoethylmethacrylate (DMAEMA) and polyethylenimine (PEI) moieties were covalently bound to the surface of polydimethylsiloxane (PDMS) or polymethylmethacrylate (PMMA) and subsequently quaternized. Physicochemical characterization of the grafted surfaces was carried out and their effect on C. albicans cell numbers was assessed using a modified Robbins device to grow the biofilms. Covalently bound quaternized polyDMAEMA (polyDMAEMAq) and PEI (PEIq) inhibited biofilm growth, with reductions up to 92%. Our approach may show promise for future application in medical devices such as catheters and prostheses.
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