期刊
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
卷 775, 期 -, 页码 89-93出版社
ELSEVIER
DOI: 10.1016/j.mrgentox.2014.09.003
关键词
DNA damage; Fish cell culture; Nanoparticles; Quantum dots; Silver; Cadmium
资金
- Cefas programme [DP282]
The increasing use of nanotechnologies will lead to significant releases of engineered nanoparticles into the aquatic environment, where their impact is still poorly characterized. In the present paper, the genotoxic and cytotoxic properties of CdS quantum dots (QDs) and silver sulphide (Ag2S) coated with methyl polyethylene glycol (M-PEG) were investigated in a rainbow trout cell line (RTG-2). The results showed that CdS QDs were highly cytotoxic at high concentrations (10 and 50 mu g/ml), and exhibited a concentration-dependent genotoxicity in the sub-toxic range (0.01-1 mu g/ml) after 24h exposure. Ag2S showed neither genotoxic nor cytotoxic effects. (C) 2014 Elsevier B.V. All rights reserved.
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