期刊
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
卷 747, 期 1, 页码 29-35出版社
ELSEVIER
DOI: 10.1016/j.mrgentox.2012.03.013
关键词
Adaptive response; Radiofrequency fields; UMTS signal; Specific absorption rate; Human blood lymphocytes; Micronuclei
The induction of an adaptive response (AR) was examined in human peripheral blood lymphocytes exposed to non-ionizing radiofrequency fields (RF). Cells from nine healthy human volunteers were stimulated for 24 h with phytohaemagglutinin and then exposed for 20 h to an adaptive dose (AD) of a 1950 MHz RF UMTS (universal mobile telecommunication system) signal used for mobile communications, at different specific absorption rates (SAR) of 1.25, 0.6, 0.3, and 0.15 W/kg. This was followed by treatment of the cells at 48 h with a challenge dose (CD) of 100 ng/ml mitomycin C (MMC). Lymphocytes were collected at the end of the 72 h total culture period. The cytokinesis-block method was used to record the frequency of micronuclei (MN) as genotoxicity end-point. When lymphocytes from six donors were pre-exposed to RF at 0.3 W/kg SAR and then treated with MMC, these cells showed a significant reduction in the frequency of MN, compared with the cells treated with MMC alone: this result is indicative of induction of AR. The results from our earlier study indicated that lymphocytes that were stimulated for 24 h, exposed for 20 h to a 900 MHz RF GSM (global system for mobile communication) signal at 1.25 W/kg SAR and then treated with 100 ng/ml MMC, also exhibited AR. These overall data suggest that the induction of AR depends on RF frequency, type of the signal and SAR. Further characterization of RF-induced AR is in progress. (C) 2012 Elsevier B.V. All rights reserved.
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