期刊
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
卷 700, 期 1-2, 页码 62-66出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mrgentox.2010.04.023
关键词
Hinokinin; Micronucleus; V79 cell; Clastogenicity
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Brazil) [2007/07211-6]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
The dibenzylbutyrolactone lignan (-)-hinokinin (HK) was obtained by partial synthesis from (-)-cubebin, isolated from the dry seeds of the pepper, Piper cubeba. In view of the trypanocidal activity of HK and its potential as a lead compound for drug development, evaluation of its possible genotoxic activity is required. We have tested HK for possible genotoxicity and evaluated the compound's effect on the activity of the clastogens doxorubicin (DXR) and methyl methanesulfonate (MMS) in the micronucleus (MN) assay with Chinese hamster lung fibroblast V79 cells. HK alone did not induce MN, at concentrations up to 128 mu M. In combined treatments, HK reduced the frequency of MN induced by MMS. With respect to DXR, HK exerted a protective effect at lower concentrations, but at higher concentrations it potentiated DXR clastogenicity. (C) 2010 Elsevier B.V. All rights reserved.
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