期刊
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
卷 656, 期 1-2, 页码 62-67出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mrgentox.2008.07.006
关键词
Preterm delivery; GSTM1; GSTT1; CYP1A1; PM10; Gene-environment interaction
资金
- Seoul Research & Business Development [2005-1547-1]
- National Research Foundation of Korea [전06A1111, 전06A1107] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
We investigated the association between the risk of preterm delivery and each metabolic gene of glutathione S-transferases mu 1 (GSTM1), theta 1 (GSTTI) and cytochrome P450IA1 (CYP1A1) along with exposure to particulate matter <10 mu m (PM10). This study was assumed to identify gene-environment interaction that increases the risk of preterm delivery. A case-control study was carried out on 117 women with preterm deliveries and 118 women with term deliveries in Seoul, Korea. Logistic regression analyses were performed to explore the impact of each gene, PM10 exposure and their interaction on the risk of preterm birth. The risk of preterm birth was associated with the GSTM1 null genotype only. Exposure to high levels of PM10 (>= 75th percentile) during the third trimester of pregnancy was associated with an increased risk of preterm birth when compared to low-level exposure to PM10 (<75th percentile). We found that exposure to high levels of PM10 during the third trimester in the presence of the GSTM1 null genotype is significantly associated with the risk of preterm delivery. This finding is biologically plausible and provides evidence for a gene-environment interaction that increases the risk of preterm birth. (C) 2008 Elsevier B.V. All rights reserved.
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