期刊
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
卷 657, 期 1, 页码 84-90出版社
ELSEVIER
DOI: 10.1016/j.mrgentox.2008.09.004
关键词
Regulatory genotoxicity testing; Potential artefacts in genotoxicity test results; Risk evaluation; Updating guidance
This symposium focused on the use of tests for chromosomal damage, and other genotoxicity measures, for detection of potentially harmful chemicals. The speakers discussed the information that has been gained over the last three decades about the use of short-term tests for genotoxicity in cultured cells and in animals (mainly rodents), and the ongoing debates about the rational use of data from such experimental systems in trying to extrapolate to an understanding of potential human risk. The overall theme was that the field of regulatory toxicology currently is over-reliant on qualitative outcomes of in vitro hazard-screening tests, generally conducted at the maximum achievable exposures, and needs a more realistic approach that incorporates in vivo exposure levels and dose-response information. (C) 2008 Elsevier B.V. All rights reserved.
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