期刊
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
卷 652, 期 2, 页码 112-121出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mrgentox.2008.01.005
关键词
chromosome translocations; background frequency; controls; fluorescence in situ hybridization
资金
- Intramural NIH HHS Funding Source: Medline
- NCI NIH HHS [P01 CA059431-070001, Y3 CO 5117, Y1 CP 9012, Y03 CO5117, P01 CA059431-080001, P01 CA059431-08, P01 CA059431-08S10001, P01 CA059431-060001] Funding Source: Medline
- NIAID NIH HHS [Y2 AI 5077] Funding Source: Medline
Chromosome translocations in peripheral blood lymphocytes of normal, healthy humans increase with age, but the effects of gender, race, and cigarette smoking on background translocation yields have not been examined systematically. Further, the shape of the relationship between age and translocation frequency (TF) has not been definitively determined. We collected existing data from 16 laboratories in North America, Europe, and Asia on TFs measured in peripheral blood lymphocytes by fluorescence in situ hybridization whole chromosome painting among 1933 individuals. In Poisson regression models, age, ranging from newborns (cord blood) to 85 years, was strongly associated with TF and this relationship showed significant upward curvature at older ages versus a linear relationship (p < 0.001). Ever smokers had significantly higher TFs than non-smokers (rate ratio (RR) = 1.19, 95% confidence interval (CI), 1.09-1.30) and smoking modified the effect of age on TFs with a steeper age-related increase among ever smokers compared to non-smokers (p < 0.00 1). TFs did not differ by gender. Interpreting an independent effect of race was difficult owing to laboratory variation. Our study is three times larger than any pooled effort to date, confirming a suspected curvilinear relationship of TF with age. The significant effect of cigarette smoking has not been observed with previous pooled studies of TF in humans. Our data provide stable estimates of background TF by age, gender, race, and smoking status and suggest an acceleration of chromosome damage above age 60 and among those with a history of smoking cigarettes. (C) 2008 Elsevier B.V. All rights reserved.
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