期刊
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
卷 711, 期 1-2, 页码 28-40出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mrfmmm.2011.01.003
关键词
Modelling; Track structure; Multi-scale; DNA damage; DNA repair
资金
- EC [FI6R-CT-2003-508842, FI6R-036465]
- National Aeronautics and Space Administration [NNJ04HF39G]
This review describes the PARTRAC suite of comprehensive Monte Carlo simulation tools for calculations of track structures of a variety of ionizing radiation qualities and their biological effects. A multi-scale target model characterizes essential structures of the whole genomic DNA within human fibroblasts and lymphocytes in atomic resolution. Calculation methods and essential results are recapitulated regarding the physical, physico-chemical and chemical stage of track structure development of radiation damage induction. Recent model extension towards DNA repair processes extends the time dimension by about 12 orders of magnitude and paves the way for superior predictions of radiation risks. (C) 2011 Elsevier B.V. All rights reserved.
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