期刊
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
卷 685, 期 1-2, 页码 38-44出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mrfmmm.2009.11.003
关键词
DNA repair; Cell differentiation; DNA damage signalling; Apoptosis; Autophagy
资金
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
To protect genomic integrity living cells that are continuously exposed to DNA-damaging insults are equipped with an efficient defence mechanism termed the DNA damage response. Its function is to eliminate DNA damage through DNA repair and to remove damaged cells by apoptosis. The DNA damage response has been investigated mainly in proliferating cells, in which the cell cycle machinery is integrated with the DNA damage signalling. The current knowledge of the mechanisms of DNA repair, DNA damage signalling and cell death of post-mitotic cells that have undergone irreversible cell cycle withdrawal will be reviewed. Evidence will be provided that the protection of the genome integrity in terminally differentiated cells is achieved by different strategies than in proliferating cells. (C) 2009 Elsevier B.V. All rights reserved.
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