期刊
MUSCLE & NERVE
卷 51, 期 2, 页码 207-213出版社
WILEY-BLACKWELL
DOI: 10.1002/mus.24296
关键词
biomarker; Duchenne muscular dystrophy; muscle; myopathy; ultrasound
资金
- NIH [R01AR060850-02]
- Howard Hughes Medical Institute (HHMI)
- Duchenne Research Fund (DRF)
- National Institutes of Health [R01 AR060850]
IntroductionMuscle pathology in Duchenne muscular dystrophy (DMD) can be quantified using ultrasound by measuring either the amplitudes of sound-waves scattered back from the tissue [quantitative backscatter analysis (QBA)] or by measuring these backscattered amplitudes after compression into grayscale levels (GSL) obtained from the images. Methods: We measured and compared QBA and GSL from 6 muscles of 25 boys with DMD and 25 healthy subjects, aged 2-14 years, with age and, in DMD, with function (North Star Ambulatory Assessment). Results: Both QBA and GSL were measured reliably (intraclass correlation0.87) and were higher in DMD than controls (P<0.0001). In DMD, average QBA and GSL measured from superficial regions of muscle increased (rho0.47, P<0.05) with both higher age and worse function; in contrast, GSL measured from whole regions of muscle did not. Conclusions: QBA and GSL measured from superficial regions of muscle can similarly quantify muscle pathology in DMD. Muscle Nerve 51: 207-213, 2015
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