期刊
MUSCLE & NERVE
卷 46, 期 3, 页码 449-453出版社
WILEY-BLACKWELL
DOI: 10.1002/mus.23488
关键词
Foxp3; GM-CSF; immunology; myasthenia; regulatory T cells; sargramostim
资金
- National Institute of Neurological Disorders and Stroke of the National Institutes of Health [NIH K08NS058800]
- National Institute of Allergy and Infectious Diseases [RO1 AI 058190]
- Muscular Dystrophy Association [MDA 134545]
- University of Illinois at Chicago, Center for Clinical and Translational Science from the National Center for Research Resources [UL1RR029879]
Introduction: In this study we describe a patient with a prolonged myasthenic crisis refractory to conventional immunomodulatory therapy who was treated with GM-CSF (granulocyte macrophage colony-stimulating factor, sargramostim). Methods: T-regulatory cell (Treg) suppressive function and Foxp3 expression were evaluated before and after treatment with GM-CSF. Results: Treatment with GM-CSF was associated with clinical improvement, expansion in the circulating numbers of Foxp3+ cells, increase in Foxp3 expression levels in Tregs, early improvement in Treg suppressive capacity for AChR-ainduced T-cell proliferation, and subsequent enhancement in Treg suppression of polyclonal T-cell proliferation. Conclusion: Although definitive conclusions cannot be drawn from a single case, the correlation with similar findings in GM-CSFtreated animals with experimental autoimmune myasthenia gravis suggests further exploration of the effects of GM-CSF in myasthenia gravis should be studied in a clinical trial setting. Muscle Nerve 46: 449453, 2012
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