ROS-MEDIATED ACTIVATION OF NF-kappa B AND FOXO DURING MUSCLE DISUSE

We examined reactive oxygen species as upstream activators of nuclear factor kappa B; (NF-kappa B) and forkhead box O (Foxo) in skeletal muscle during disuse atrophy. Call an enzyme that degrades H2O2, was overexpressed in soleus muscles via plasmid injection prior to 7 days of hindlimb immobilization. The increased catalase activity abolished immobilization-induced transactivation of both NF-kappa B and Foxo and attenuated the loss of muscle mass. Thus, H2O2 may be an important initiator of these signaling pathways that lead to muscle atrophy. Muscle Nerve 41: 110-113, 2010