期刊
MUSCLE & NERVE
卷 38, 期 4, 页码 1290-1303出版社
JOHN WILEY & SONS INC
DOI: 10.1002/mus.21141
关键词
Duchenne muscular dystrophy; endurance exercise; histochemistry; physical activity; skeletal muscle
资金
- Nash Avery Search for Hope Research Fund
- University of Minnesota, and a grant from the Muscular Dystrophy Association [MDA4143]
- NATIONAL INSTITUTE ON AGING [K01AG020990] Funding Source: NIH RePORTER
The purpose of this study was to determine the extent to which hindlimb muscles of mdx mice adapt to a voluntary endurance type of exercise. mdx and C57BL mice engaged in 8 weeks of wheel running or maintained normal cage activities. Beneficial adaptations that occurred in mdx mice included changes in muscle mass, fiber size, and fiber types based on myosin heavy chain (MHC) isoform expression. These adaptations occurred without increases in fiber central nuclei and embryonic MHC expression. An undesirable outcome, however, was that muscle mitochondrial enzyme activities did not improve with exercise in mdx mice as they did in C57BL mice. Cellular remodeling of dystrophic muscle following exercise has not been studied adequately. In this study we found that some, but not all, of the expected adaptations occurred in mdx mouse muscle. We must better understand these (non) adaptations in order to inform individuals with DMID about the benefits of exercise.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据