期刊
MULTIPLE SCLEROSIS JOURNAL
卷 25, 期 13, 页码 1715-1718出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458518791683
关键词
Biomarkers; hypoxia; inflammation
Hypoxia has been associated with multiple sclerosis (MS) and is an important area of research. Hypoxia can exacerbate inflammation via the prolylhydroxylase pathway. Inflammation can also trigger hypoxia by damaging mitochondria and endothelial cells to impair blood flow regulation. We hypothesize that there is a hypoxia-inflammation cycle in MS which plays an important role in MS disease progression. Therapies that break this cycle may be an interesting area of exploration for treatment of MS.
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