期刊
MULTIPLE SCLEROSIS JOURNAL
卷 20, 期 2, 页码 135-140出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458514520911
关键词
Multiple sclerosis; epigenetics; DNA methylation; histone modification; microRNA
资金
- Multiple Sclerosis Research Australia Postdoctoral Fellowship
- Australian Research Council Future Fellowship
It is now well established that both genetic and environmental factors contribute to and interact in the development of multiple sclerosis (MS). However, the currently described causal genetic variants do not explain the majority of the heritability of MS, resulting in missing heritability'. Epigenetic mechanisms, which principally include DNA methylation, histone modifications and microRNA-mediated post-transcriptional gene silencing, may contribute a significant component of this missing heritability. As the development of MS is a dynamic process potentially starting with inflammation, then demyelination, remyelination and neurodegeneration, we have reviewed the dynamic epigenetic changes in these aspects of MS pathogenesis and describe how environmental risk factors may interact with epigenetic changes to manifest in disease.
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