期刊
MULTIPLE SCLEROSIS JOURNAL
卷 19, 期 11, 页码 1533-1538出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458513477925
关键词
Multiple sclerosis; JC virus; natalizumab; STRATIFY-JCV; anti-JCV antibodies; epidemiology; infection risk; international study; antibody prevalence; immunosuppressant therapy; brain infection
资金
- Biogen Idec Inc.
- Elan Pharmaceuticals Inc.
JC virus (JCV) is an opportunistic virus known to cause progressive multifocal leukoencephalopathy. Anti-JC virus (Anti-JCV) antibody prevalence in a large, geographically diverse, multi-national multiple sclerosis (MS) cohort was compared in a cross-sectional study. Overall, anti-JCV antibody prevalence was 57.6%. Anti-JCV antibody prevalence in MS patients ranged from approximately 47% to 68% across these countries: Norway, 47.4%; Denmark, 52.6%; Israel, 56.6%; France, 57.6%; Italy, 58.3%; Sweden, 59.0%; Germany, 59.1%; Austria, 66.7% and Turkey, 67.7%. Prevalence increased with age (from 49.5% in patients < 30 years of age to 66.5% in patients 60 years of age; p < 0.0001 comparing all age categories), was lower in females than in males (55.8% versus 61.9%; p < 0.0001) and was not affected by prior immunosuppressant or natalizumab use.
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