4.3 Article

Quality of life, depression and fatigue in mildly disabled patients with relapsing-remitting multiple sclerosis receiving subcutaneous interferon beta-1a: 3-year results from the COGIMUS (COGnitive Impairment in MUltiple Sclerosis) study

期刊

MULTIPLE SCLEROSIS JOURNAL
卷 17, 期 8, 页码 991-1001

出版社

SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458511401943

关键词

cognitive function; depression; fatigue; interferon beta-1a; longitudinal study; quality of life; relapsing-remitting multiple sclerosis

资金

  1. European Biomedical Foundation, Rome, Italy
  2. Merck Serono
  3. Biogen
  4. Biogen-Dompe
  5. sanofi-aventis
  6. Serono Symposia International Foundation
  7. Bayer Schering
  8. Novartis
  9. Teva Pharmaceutical Industries

向作者/读者索取更多资源

Background: The precise relationships among quality of life, depression, fatigue and cognitive impairment in multiple sclerosis (MS) are complex and poorly understood. Objective: To assess the effects of subcutaneous interferon beta-1a on quality of life, depression and fatigue over 3 years in the COGIMUS study, and to examine the relationship between these outcomes and baseline cognitive status. Methods: COGIMUS was an observational 3-year trial assessing cognitive function in 459 patients with relapsing-remitting MS treated with subcutaneous interferon beta-1a. Results: In total, 331 patients completed the study (168 received interferon beta-1a, 44 mu g subcutaneously three times weekly, and 163 received interferon beta-1a, 22 mg subcutaneously three times weekly). Mean MS Quality of Life-54 (MSQoL-54) composite scores did not change over time. There were no significant differences between groups in MSQoL-54 composite scores when patients were grouped by treatment dose and baseline cognitive status. Mean (standard deviation) Hamilton Depression Rating Scale score decreased from 6.8 (4.9) at baseline to 5.8 (5.9) at year 3. Mean total Fatigue Impact Scale scores were low (<30) at all time points. Conclusion: Quality of life, depression and fatigue remained largely stable over 3 years; no effects of treatment dose or baseline cognitive status were found.

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